Asian Journal of Research and Reports in Hepatology <p style="text-align: justify;"><strong>Asian Journal of Research and Reports in Hepatology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRRHE/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Hepatology’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> en-US (Asian Journal of Research and Reports in Hepatology) (Asian Journal of Research and Reports in Hepatology) Wed, 13 Feb 2019 00:00:00 +0000 OJS 60 Protective Potential of Anacardium occidentale Leaves against Paracetamol-induced Hepatotoxicity <p>This study investigates the protective effects of the ethanolic extract of <em>Anacardium occidentale</em> leaves on paracetamol induced liver toxicity in Wistar rats. Twenty five (25) female Wistar rats were randomly divided into five (5) groups of five (5) rats each. The groups were designated as follows; A, B, C, D and E. Group A served as the normal control, group B served as the negative control and received 1000 mg/kg of paracetamol only, group C received 1000 mg/kg of paracetamol for three days then treated with 250 mg/kg of <em>A.</em> <em>occidentale</em> extract, group D received 1000 mg/kg of paracetamol for three days then treated with 500 mg/kg of <em>A.</em> <em>occidentale</em> extract and group E received 1000 mg/kg of paracetamol concurrently with 500 mg/kg of the extract for 4 weeks respectively. After the last day of administration, the rats were anaesthetized using ketamine and the liver tissues were harvested for histopathological examination. The result revealed significant (<em>P</em>&lt;0.05) decrease in body weight of animals in the tested groups compared to the control after paracetamol administration. The histopathological findings revealed severe focal aggregation of inflammatory cells (SFAIC), severe hepatocellular necrosis in the negative control and showed regeneration of hepatic tissues, which was significant in the group that received high doses of the extract (500 mg/kg). It can be deduced that the ethanolic extract of <em>A.</em> <em>occidentale</em> has protective effect against liver toxicity and should be recommended as an alternative traditional treatment.</p> I. J. Okafor, E. O. Nweke, J. K. Opara ##submission.copyrightStatement## Wed, 13 Feb 2019 00:00:00 +0000 Ehrlich Ascites Carcinoma Bearing Mice as Model of Human Hepatocellular Carcinoma <p><strong>Aims: </strong>Ehrlich ascites carcinoma (EAC) is a transplantable neoplasia from a malign epithelium; it is a form of ascites when inoculated into the intraperitoneal cavity. This study aimed to investigate the effects of EAC and human hepatocellular carcinoma (HCC) on the liver in mice and human.&nbsp;</p> <p><strong>Methodology:</strong> A total of 10 female Albino mice and 10 blood samples and liver biopsy from humans were used in this work; mice were divided into two equal groups,&nbsp; group 1, control mice; group 2, EAC; Group 3, control humans collected from healthy male and group 4, HCC include patients infected with HCC. Blood samples and liver tissues were collected from all groups.</p> <p><strong>Results:</strong> The obtained results showed increase in liver enzymes activity (AST, ALT and ALP), and decrease level of albumin in serum, also changes in histopathological and proliferating cell nuclear antigen (PCNA) expressions in liver sections in EAC and HCC when compared to the control group of mice and humans respectively.</p> <p><strong>Conclusion:</strong> It could be concluded that EAC bearing mice lead to a same defect on liver enzymes, histopathological and immunohistochemical which simulates and corresponds the same problems in the human HCC. We recommend using Ehrlich ascites carcinoma (EAC) as a model for human hepatocellular carcinoma (HCC), which saves time and money in addition to the possibility of studying the tumor pathogenesis and development of anti-tumorigenic agents.</p> Thulfiqar F. Mutar, Maha Abo Gazia, Seham B. Salem, Ezar H. Hammed, Ehab Tousson ##submission.copyrightStatement## Thu, 18 Jul 2019 00:00:00 +0000