An Assessment of Hepatoprotective Activity of Aloe barbadensis on Rat Model with Safety Profile Analysis
Tasin Islam Pranto
Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka-1205, Bangladesh.
Md. Rahmat Ullah
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md. Mahbubur Rahman
Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh.
FM Sharifuzzaman Shohan
Department of Pharmacy, Primeasia University, Bangladesh.
Juliana Aditi Baroi
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Puja Bhowmik
Department of Pharmacy, University of Science & Technology, Chittagong, Bangladesh.
Md. Abdullah Hil Baky Rupak
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka , 1229, Bangladesh.
Tanvir Chowdhury
Department of Pharmacy, University of Chittagong, Bangladesh.
Rafat Tashin *
Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka-1205, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
The art of employing herbs and herbal medications to preserve health and prevent, is an ancient practice. To continue the legacy we selected Aloe barbadensis extract to assess its lipid lowering effect on rat model. Here, it has been observed that Groups 5 and 6 showed statistically significant results (P<0.05) in the renal function test. Groups 4 and 5 exhibited significant levels of creatinine. When considering the SGPT and SGOT, it was seen that the SGOT levels in groups 5 and 6 were statistically significant (P<0.05). On the other hand, the SGOT levels were found to be significant in groups 6 and 7. In the instance of the lipid profile test, the outcome was found to be statistically significant (P<0.05) in groups 4, 5, and 6 for the total cholesterol level. In the case of triglyceride levels, however, there is no result that can be considered statistically significant. In the case of groups 5 and 6, the HDL level exhibited statistically significant (P<0.05) outcomes, but the LDL level showed statistically significant results in the case of group 6.
Keywords: Aloe barbadensis, SGPT, herbal medicine, triglyceride, phytopharmacology, cholesterol