An Assessment of Hepatoprotective Activity of Aloe barbadensis on Rat Model with Safety Profile Analysis
Tasin Islam Pranto
Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka-1205, Bangladesh.
Md. Rahmat Ullah
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md. Mahbubur Rahman
Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh.
FM Sharifuzzaman Shohan
Department of Pharmacy, Primeasia University, Bangladesh.
Juliana Aditi Baroi
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Puja Bhowmik
Department of Pharmacy, University of Science & Technology, Chittagong, Bangladesh.
Md. Abdullah Hil Baky Rupak
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka , 1229, Bangladesh.
Tanvir Chowdhury
Department of Pharmacy, University of Chittagong, Bangladesh.
Rafat Tashin *
Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka-1205, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
The art of employing herbs and herbal medications to preserve health and prevent, is an ancient practice. To continue the legacy we selected Aloe barbadensis extract to assess its lipid lowering effect on rat model. Here, it has been observed that Groups 5 and 6 showed statistically significant results (P<0.05) in the renal function test. Groups 4 and 5 exhibited significant levels of creatinine. When considering the SGPT and SGOT, it was seen that the SGOT levels in groups 5 and 6 were statistically significant (P<0.05). On the other hand, the SGOT levels were found to be significant in groups 6 and 7. In the instance of the lipid profile test, the outcome was found to be statistically significant (P<0.05) in groups 4, 5, and 6 for the total cholesterol level. In the case of triglyceride levels, however, there is no result that can be considered statistically significant. In the case of groups 5 and 6, the HDL level exhibited statistically significant (P<0.05) outcomes, but the LDL level showed statistically significant results in the case of group 6.
Keywords: Aloe barbadensis, SGPT, herbal medicine, triglyceride, phytopharmacology, cholesterol
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References
Bhawna S, Kumar SU. Hepatoprotective activity of some indigenous plants. Int J Pharm Tech Res. 2009;4:1330-4.
Nadeem MPC, Dandiya PC, KV, Pasha M, Imran D, Balani K, Vohora SB. Hepatoprotective activity of Solanum nigrum fruits. Fitoterapia. 1997;68:245:51
FM SS, Juliana AB, Bornila M, Puja B, Nur-Neasha D, Rafat T. An assessment of hepato-protective activity of Psidium guajava fruit extract against hepatic injured rodent model. Asian Journal of Medical Principles and Clinical Practice. 2023;6(2): 240-5.
Islam M, Rupak AH, Nasrin N, Chowdhury MM, Sen P, Foysal AU, Uddin MJ, Ferdous J, Tahsin MR, Aktar F, Kabir S. An evaluation of potential hepato–protective properties of Hylocereus undatus fruit in experimental rat model. Biomedical Journal of Scientific & Technical Research. 2022;43(2):34405-16.
Baroi JA, Hossian MR, Chowdhury MM, Dolon NN, Maliha F, Rupak MA, Lima NN, Ullah MR, Tahsin R. An assessment of anti-hyperlipidemic potentialities of ethanolic extract of Hemidesmus indicus in high fat induced rat model. Asian Journal of Food Research and Nutrition. 2023;2(4): 323-30.
Mim IJ, Peya FY, Chowdhury MM, Khan TR, Mandal SK, Maliha F, Alam M, Rahman T, Tashin R. An evaluation of anti-diabetic activity of ethanolic extract of Asparagus racemosus in alloxan induced rat model. International Journal of Advances in Nephrology Research. 2023; 6(1):60-8.
Baroi JA, Hossian MR, Chowdhury MM,Dolon NN, Maliha F, Rupak MA, Lima NN,Ullah MR, Tahsin R. An assessment ofanti-hyperlipidemic potentialities ofethanolic extract of Hemidesmus indicus inhigh fat induced rat model. Asian Journalof Food Research and Nutrition. 2023;2(4):323-30.
Yang L, Stöckigt J. Trends for diverse production strategies of plant medicinal alkaloids. Natural Product Reports. 2010; 27(10):1469-1479.
Saxena M, Saxena J, Nema R, Singh D, Gupta A. Phytochemistry of medicinal plants. Journal of Pharmacognosy and Phytochemistry. 2013;1(6):168-18210.
Rupak MA, Chowdhury MM, Shurovi FS, Ferdous J, Tahsin MR, Sarif S, Hasan MM, Chowdhury JA, Kabir S, Chowdhury AA, Aktar F. An Evaluation of Analgesic and Anti-Inflammatory Activity of Ethanolic Extract of Cynodon dactylon on Stressed Rodent Model. Biomedical Journal of Scientific & Technical Research. 2022; 42(3):33550-7
Heinemann C, Hylckama V, Van Johan ET, Janssen DB, Busscher HJ, Van Der Mei HC, Reid G. Purification and characterization of a surface-binding protein from Lactobacillus fermentum RC-14 that inhibits adhesion of Enterococcus faecalis 1131. FEMS Microbiol Lett. 2000; 90:177–180.
Mahadevi M, Vinotha P, Uma V. Anti–hyperglycemic activity of Aloe vera ethanolic extract against mouse 3T3-L1 adipocyte cell line. International Journal of Applied Chemical and Biological Sciences. 2020;1(3):58-66.
Bista R, Ghimire A, Subedi S. Phytochemicals and antioxidant activities of Aloe Vera (Aloe barbadensis). J Nut Sci Heal Diet. 2020;1(1):25-36.
Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological update properties of Aloe vera and its major active constituents. Molecules. 2020; 25(6):1324.
Liu C, Cui Y, Pi F, Cheng Y, Guo Y, Qian H. Extraction, purification, structural characteristics, biological activities and pharmacological applications of acemannan, a polysaccharide from aloe vera: A review. Molecules. 2019;24(8): 1554.
Elias MF, Elias PK, Seliger SL, Narsipur SS, Dore GA, Robbins MA. Chronic kidney disease, creatinine and cognitive functioning. Nephrology Dialysis Transplantation. 2009;24(8):2446-52.
Yanardağ R, Bolkent Ş, Özsoy‐Saçan Ö, Karabulut‐Bulan Ö. The effects of chard (Beta vulgaris L. var. cicla) extract on the kidney tissue, serum urea and creatinine levels of diabetic rats. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2002;16(8):758-761.
Shimmi SC, Jahan N, Sultana N. Effect of Ashwagandha (Withania somnifera) root extract against gentamicin induced changes of serum urea and creatinine levels in rats. Journal of Bangladesh Society of Physiologist. 2011;6(2):84-9.
Yuneldi RF, Saraswati TR, Yuniwarti EY. Profile of SGPT and SGOT on male rats (Rattus norvegicus) hyperglycemic after giving Insulin leaf extract (Tithonia diversifolia). Biosaintifika: Journal of Biology & Biology Education. 2018;10(3): 519-25.
Mahdi C, Pratama CA, Pratiwi H. Preventive study garlic extract water (allium sativum) toward SGPT, SGOT, and the description of liver histopathology on rat (Rattus norvegicus), which were exposed by rhodamine B. InIOP Conference Series: Materials Science and Engineering. 2019;546(6):062015). IOP Publishing.
Hossain MS, Ahmed M, Islam A. Hypolipidemic and hepatoprotective effects of different fractions of methanolic extract of Momordica charantia (Linn.) in alloxan induced diabetic rats. International Journal of Pharmaceutical Sciences and Research. 2011;2(3):601.
Yousofvand N, Soltany A. Effects of hydroalcoholic extract of dill (Anethum graveolens) on the serum levels of blood lipids cholesterol, triglycerides, LDL and HDL in male NMRI mice. J Pharmaceut Chem Biol Sci. 2015: 114-21.
Nofianti T, Nurmayasari S, Priatna M, Ruswanto R, Nurfatwa M. The effect of the ethanolic extract of Asam Jawa leaf (Tamarindus Indica L.) in total cholesterol, triglyceride, LDL and HDL concentration on
Mirzaie H, Johari H, Najafian M, Kargar H. Effect of ethanol extract of root turnip (Brassica rapa) on changes in blood factors HDL, LDL, triglycerides and total cholesterol in hypercholesterolemic rabbits. Advances in Environmental Biology. 2012:2796-812.