Asian Journal of Research and Reports in Hepatology 2020-08-13T06:28:57+00:00 Asian Journal of Research and Reports in Hepatology Open Journal Systems <p style="text-align: justify;"><strong>Asian Journal of Research and Reports in Hepatology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRRHE/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Hepatology’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> Hepatotoxicity Assessment of a Polyherbal Mixture in Exposed Wistar Rats 2020-08-13T06:28:57+00:00 Godswill J. Udom Jude E. Okokon John A. Udobang Nkechi J. Onyeukwu Daniel N. Obot Ikanna E. Asuquo <p>The study evaluates the toxicity concern of a polyherbal mixture (Dr Iguedo Goko Cleanser®) on liver function parameters and liver histoarchitecture of exposed Wistar rats of both gender. Thirty (30) Wistar rats of both genders were randomly allotted to (6) six groups (5/group). Groups 1 and 4 were controls and received 10 mL/kg body weight of distilled water. Groups 2-3 and 5-6 received high (476.24 mg/kg) and low (158.75 mg/kg) doses of the polyherbal mixture respectively. On 62<sup>nd</sup> day, the animals were euthanized under diethyl ether anaesthesia and sacrificed. Blood samples were collected via cardiac puncture for biochemical analysis. From each animal, the liver was eviscerated, weighed and fixed in 10% buffered formalin for histopathological examination. Results presented a significant (p&lt;0.05) increase in ALT activity for high dose female (HDF) rats; while a decrease was recorded for low dose male (LDM) rats. Significant reduction in AST activity was recorded for the male rats. Whereas, decreased and increased AST activities were respectively recorded for high and low dose female rats. ALP activities were significantly reduced and elevated in the exposed male and female rats respectively. The histopathology of the liver revealed degrees of pathologies such as tissue degeneration, hypertrophy, hyperplasia, ruptured bile ducts amongst others. Findings suggest utmost caution on chronic use of the polyherbal mixture and avoidance whenever possible, as its hepatotoxic potentials are considerable.</p> 2020-08-13T00:00:00+00:00 ##submission.copyrightStatement## Accessory Hepatic Lobe Strangulated in Post-traumatic Diaphragmatic Hernia 2020-02-15T07:32:04+00:00 Issam Hamrerras Abdelillah El. Bakouri Sylvestre Kabura Fatimazahra Bensardi Khalid El. Hattabi Abdelaziz Fadil <p>The accessory lobe of the liver is a rare morphological variation. It is frequently found in the lower segments. Riedel's lobe is the best known of the accessory lobes of the liver and corresponds to an enlargement of segments V and VI with an incidence of 3.3% to 14.5%. It is often diagnosed incidentally and sometimes revealed by a complication, the association of a strangulated post-traumatic diaphragmatic hernia containing the Riedel's lobe is an unusual situation. The present study report the first case of this association in a patient, admitted in emergency after a violent closed thoraco-abdominal trauma following a public road accident four days earlier. The physical examination was poor and the symptoms were non-specific. The diagnosis was made by preoperative imaging, the chest X-ray found the digestive gas into the thoracic cavity, the thorax and abdominal CT scan showed a solution of continuity of the right anteromedial part of the diaphragm through which protrudes in the intrathoracic the segment of the liver with parenchyma perfusion disorders and a dilated colonic segment in the right hemi thoracic cavity without signs of pneumatosis. There was a repression of the mediastinum organs to the left thoracic cavity. The surgical treatment consisted in a reduction of the hernia content, which was viable with the diaphragmatic defect closure with non absorbable interrupted suture. The post operative was uneventfull. The aim of this study is to show the possibility of this association which must be kept in mind in case of violent closed thoraco-abdominal trauma or basithoracic injury.</p> 2020-02-15T00:00:00+00:00 ##submission.copyrightStatement## Hepatic Crisis in Sickle Cell Anaemia – A Case Report 2020-02-22T09:32:28+00:00 Okechukwu C. <p>Hepatic crisis in sickle cell disease (SCD) has been reported in about 10% of adults but occurs rarely in children. This is a report of a case of a hepatic crisis in a 15-year-old male with SCD with the aim of highlighting the presentation, diagnosis and management. A 15-year-old male, known SCD patient (homozygous Haemoglobin SS) presented with a 6-day history of worsening jaundice, 5-day history of fever and a 4-day history of abdominal pain and vomiting. On examination, he was deeply jaundiced with a greenish tinge, in painful distress with marked right hypochondrial tenderness and hepatomegaly of 12 cm. (compared to no palpable liver when he was seen a week prior to presentation). His haematocrit done was 13% (compared to a haematocrit of 26% a week to presentation). Serum aspartate and alanine aminotransferase were mildly elevated. He also had conjugated hyperbilirubinemia. An abdominal ultrasound scan showed diffuse hepatomegaly. Hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV), Human immunodeficiency virus (HIV) I and II assay were negative. He was managed with serial blood transfusions. He also received antibiotics and analgesics. He made a rapid clinical recovery and was discharged home after 4 days on admission. This case is being reported to provide insight into the presentation, diagnosis and management of this condition. It is especially useful for clinicians who are not familiar with the intrahepatic vaso- occlusive syndromes in sickle cell disease.</p> 2020-02-22T00:00:00+00:00 ##submission.copyrightStatement## Inflammatory Stenosis of the Main Bile Duct: A Case Report 2020-05-02T12:19:48+00:00 B. Daif A. Elkarouachi R. Boufettal D. Reguibi S. R. Jai F. Chehab <p>Inflammatory stenosis of the main bile duct is rare and not well characterized. We report a 47-year-old male, in whom obstructive jaundice was caused by inflammatory stenosis of the main bile duct. The patient was admitted due to jaundice and an abdominal ultrasound revealed intrahepatic bile duct dilatation, distended gallbladder and a mass around the main bile duct. MRI revealed the mass in the site. We diagnosed this condition as main bile duct occlusion of unknown origin and considering this as emergency situation, we performed laparotomy. Segmental resection of the main bile duct and jejunal hepatic shunt on Y-branch were performed. Although image analyses suggested a mass lesion, histology confirmed nonspecific cholangitis.</p> 2020-05-02T00:00:00+00:00 ##submission.copyrightStatement##