Asian Journal of Research and Reports in Hepatology https://journalajrrhe.com/index.php/AJRRHE <p style="text-align: justify;"><strong>Asian Journal of Research and Reports in Hepatology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRRHE/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Hepatology’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> Asian Journal of Research and Reports in Hepatology en-US Asian Journal of Research and Reports in Hepatology Association between Pyridoxal-5'-Phosphate Levels, Liver Homogenates and Serum Activities of Aminotransferases and De Ritis Ratio amongst Alcoholic Hepatitis Patients https://journalajrrhe.com/index.php/AJRRHE/article/view/30100 <p><strong>Aim:</strong> The current study assessed the association between Pyridoxal-5'-phosphate (PLP) levels, liver and serum activities of aminotransferases (ALT and AST) and De Ritis ratio (DRR) in ten subjects with alcoholic hepatitis (test group -TG) and 10 healthy subjects without alcoholic hepatitis (control group-CG) with mean age of 41 years of both genders who were attending the University of Calabar Teaching Hospital, Calabar, Nigeria.</p> <p><strong>Study Design</strong><strong>:</strong> The current study was a randomized experimental designed work.</p> <p><strong>Place and Duration of Study: </strong>The study carried out in Chemical Pathology Unit, Department of Medical Lab Sciences, University of Calabar, Nigeria between December 2014 and December 2016.</p> <p><strong>Methodology:</strong> Appropriate samples were collected from both TG and CG after 8-10 hours fasting and treated using standard procedures. PLP was determined by techniques of Lumeng and co-workers, 1981 (reagents from New England Nuclear, Massachusetts, USA). Hepatic protein levels and aminotransferase activities were determined by spectrophotometric methods, (reagents from Sigma- Aldrich Company, USA). Liver biopsy specimens were obtained with a Klatskin needle for histology.</p> <p><strong>Results:</strong> Before PLP supplementation of liver homogenates a significant decreased in PLP levels, increased liver ALT and decreased AST activities were observed in test group. After one month of pyridoxine supplementation, there was a significant increase (p&lt;0.02) in plasma PLP level in all groups with decreased serum AST and increased serum ALT activities ,while liver ALT and AST activities increased significantly (p&lt;0.005) resulting to a decrease serum DRR (p&lt;0.001) in test group.</p> <p><strong>Conclusion:</strong> PLP depletion may be partially responsible for the low serum DRR which is reputed to be a typical potent, non-invasive, economical and dynamic prognostic biomarker of alcoholic hepatitis.</p> Forwah Jacques Ndeh Ebot Walter Ojong Uwem Okon Akpan Immaculate Ihuoma Ekeagba Mohmbashagle Ngangnchi Smella ##submission.copyrightStatement## 2021-02-12 2021-02-12 1 10 Endovascular Management of Budd Chiari Syndrome - A Case Report https://journalajrrhe.com/index.php/AJRRHE/article/view/30101 <p><strong>Background: </strong>Budd Chiari Syndrome denotes a group of rare diseases which have been studied with considerable interest by clinicians across the world. The clinical presentation and investigation results vary in most cases making the diagnosis a challenge. Although the treatment protocols are published in literature, much of it comes from expert opinions rather than research-based findings. The use of medical therapy, thrombolysis and interventional procedures are well known. However, the order of preference while choosing the treatment option depends on each case and must be considered depending on local expertise.</p> <p><strong>Case Summary: </strong>We present a case of a young male patient with no significant medical history who presented with lower limb oedema and pain. The laboratory findings were within normal range and the ultrasound scan revealed mild hepatomegaly. On further imaging we found a retrohepatic vena caval occlusion which was amenable to endovascular intervention. This patient was treated with angioplasty and stenting with satisfactory clinical outcome. The decision to proceed with an endovascular first approach is highlighted in our case report.</p> <p><strong>Conclusion: </strong>The traditional treatment strategies for BCS include medical therapy, thrombolysis or surgical portosystemic shunt creations which involve significant morbidity and procedure related complications. It is worthwhile to select patients with amenable lesions to undergo endovascular treatment in the initial stages of management. This will lead to good clinical outcomes and prevent long term liver damage. This approach has been highlighted in our case report and we recommend its use with the availability of local expertise.</p> Uzma Sadia Hasan Khalaf Venkatesh Reddy ##submission.copyrightStatement## 2021-04-09 2021-04-09 11 15